Quarterly report pursuant to Section 13 or 15(d)

2. Summary of Significant Accounting Policies (Details)

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2. Summary of Significant Accounting Policies (Details) - shares
3 Months Ended
Mar. 31, 2018
Mar. 31, 2017
Antidilutive shares excluded from EPS 61,939,445 43,565,806
Options [Member]    
Antidilutive shares excluded from EPS 37,301,300 29,974,256
Warrants [Member]    
Antidilutive shares excluded from EPS 17,590,812 9,064,317
Convertible Notes [Member]    
Antidilutive shares excluded from EPS 7,047,333 4,527,233